Publications 

Featured Publications

2024

Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry Charlie H. T. Kwok, Erika K. Harding, Nicole E. Burma, Tamara Markovic, Nicolas Massaly, Nynke J. van den Hoogen, Sierra Stokes-Heck, Eder Gambeta, Kristina Komarek, Hye Jean Yoon, Kathleen E. Navis, Brendan B. McAllister, Julia Canet-Pons, Churmy Fan, Rebecca Dalgarno, Evgueni Gorobets, James W. Papatzimas, Zizhen Zhang, Yuta Kohro, Connor L. Anderson, Roger J. Thompson, Darren J. Derksen, Jose A. Morón, Gerald W. Zamponi & Tuan Trang. Nat Commun 15, 6264 (2024). https://doi.org/10.1038/s41467-024-50657-7

Expression of GAD2 in excitatory neurons projecting from the ventrolateral periaqueductal gray to the locus coeruleus. Erika K Harding, Zizhen Zhang, Julia Canet-Pons, Sierra Stokes-Heck, Tuan Trang, Gerald W Zamponi. iScience 27, (2024) DOI: https://doi.org/10.1016/j.isci.2024.109972

Anatomy and Physiology of Pain. Charlie H.T. Kwok, Tuan Trang. Managing Pain in Children and Young People: A Clinical Guide. Chapter 3. (2024) DOI: https://doi.org/10.1002/9781119645641.ch3

Targeting Pannexin-1 Channels: Addressing the ‘Gap’ in Chronic Pain. Brendan B McAllister, Sierra Stokes-Heck, Erika K Harding, Nynke J van den Hoogen, Tuan Trang. CNS Drugs 38, (2024). DOI: https://doi.org/10.1007/s40263-024-01061-8

2023

Sex Differences in Plasma, Adipose Tissue, and Central Accumulation of Cannabinoids, and Behavioral Effects of Oral Cannabis Consumption in Male and Female C57BL/6 Mice Nada A Sallam, Colleen S Peterson, Samantha L Baglot, Yuta Kohro, Tuan Trang, Matthew N Hill, Stephanie L Borgland. Int J of Neuropsychopharmacol 26(11), 773–783 (2023) DOI: https://doi.org/10.1093/ijnp/pyad055

The Future Is Bright: Highlighting Trainee Contributions to the Canadian Journal of Pain. Hance Clarke, Mariana Bueno, Erika Harding, Tuan Trang, Jason J McDougall. Can. J. Pain 7(2), 2287032 (2023). DOI: https://doi.org/10.1080/24740527.2023.2287032

Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol. Erika K Harding, Ivana A Souza, Maria A Gandini, Vinícius M Gadotti, Md Yousof Ali, Sun Huang, Flavia TT Antunes, Tuan Trang, Gerald W Zamponi. Br. J. Pharmacol. 180(12), 1616-33 (2023). DOI: https://doi.org/10.1111/bph.16035

Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks−American Pain Society−American Academy of Pain Medicine Pain Taxonomy Diagnostic Criteria for Acute Needle Pain. William T Zempsky, Marsha Campbell-Yeo, Christine T Chambers, Lindsey L Cohen, Lucia Gagliese, Charlie HT Kwok, Tuan Trang, Bonnie Stevens, Anna Taddio, Terri Voepel-Lewis, Neil L Schechter. J. Pain Res. 24(3), 387-402 (2023). DOI: https://doi.org/10.1016/j.jpain.2022.09.018

2022

Cannabinoids in Chronic Pain: Therapeutic Potential Through Microglia Modulation. Nynke J van den Hoogen, Erika K Harding, Chloé ED Davidson, Tuan Trang. Front. Neural Circuits 15, 816747 (2022). DOI: https://doi.org/10.3389/fncir.2021.816747

Tackling the opioid crisis: Novel mechanisms and clinical perspectives. Heather Leduc‐Pessah, Tuan Trang. J Neurosci Res. 100(1), 5-9 (2022). DOI: 10.1002/jnr.24964

Spinal A3 adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats. Heather Leduc‐Pessah, Cynthia Xu, Churmy Y Fan, Rebecca Dalgarno, Yuta Kohro, Sydney Sparanese, Nikita N Burke, Kenneth A Jacobson, Christophe Altier, Daniela Salvemini, Tuan Trang. J Neurosci Res. 100(1), 251-264 (2022). DOI: https://doi.org/10.1002/jnr.24869

Maternal and iatrogenic neonatal opioid withdrawal syndrome: Differences and similarities in recognition, management, and consequences. Lisa Isaac, Nynke J van den Hoogen, Sharifa Habib, Tuan Trang. J Neurosci Res. 100(1), 373-95 (2022). DOI: https://doi.org/10.1002/jnr.24811

2021

Identifying the Neurodevelopmental Differences of Opioid Withdrawal. Nynke J van den Hoogen, Charlie HT Kwok, Tuan Trang. Cell Mol Neurobiol. 41(5), 1145-55 (2021). DOI: 10.1007/s10571-020-01035-6

Role of Primary Afferents in Arthritis Induced Spinal Microglial Reactivity. Charlie HT Kwok, Yuta Kohro, Michael Mousseau, Melissa S O’Brien, John R Matyas, Jason J McDougall, Tuan Trang. Front Immunol. 12, 626884 (2021). DOI: 10.3389/fimmu.2021.626884

2020

Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling. Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang, Christophe Altier. Mol Brain 13, 1-14 (2020).

Spinal interleukin-6 contributes to central sensitisation and persistent pain hypersensitivity in a model of juvenile idiopathic arthritis. Charlie HT Kwok, Annastazia E Learoyd, Julia Canet-Pons, Tuan Trang, Maria Fitzgerald. Brain, Behavior, and Immunity 90, 145-54 (2020). https://doi.org/10.1016/j.bbi.2020.08.004

A dynamic role for dopamine receptors in the control of mammalian spinal networks. Simon A Sharples, Nicole E Burma, Joanna Borowska-Fielding, Charlie HT Kwok, Shane EA Eaton, Glen B Baker, Celine Jean-Xavier, Ying Zhang, Tuan Trang, Patrick J Whelan. Scientific Rep 10(1), 16429 (2020). DOI: 10.1038/s41598-020-73230-w

Chronic morphine-induced changes in signaling at the A3 adenosine receptor contribute to morphine-induced hyperalgesia, tolerance, and withdrawal. Timothy M Doyle, Tally M Largent-Milnes, Zhoumou Chen, Vasiliki Staikopoulos, Emanuela Esposito, Rebecca Dalgarno, Churmy Fan, Dilip K Tosh, Salvatore Cuzzocrea, Kenneth A Jacobson, Tuan Trang, Mark R Hutchinson, Gary J Bennett, Todd W Vanderah, Daniela Salvemini. JPET 374(2), 331-341 (2020). DOI: https://doi.org/10.1124/jpet.120.000004

Pannexin 1 Channels as a Therapeutic Target: Structure, Inhibition, and Outlook. Kathleen E Navis, Churmy Y Fan, Tuan Trang, Roger J Thompson, Darren J Derksen. ACS Chem Neurosci. 11(15), 2163-2172 (2020). DOI: 10.1021/acschemneuro.0c00333.

2019

A dynamic role for dopamine receptors in the control of mammalian spinal networks. Simon A Sharples, Nicole E Burma, Joanna Borowska-Fielding, Charlie HT Kwok, Shane EA Eaton, Glen B Baker, Celine Jean-Xavier, Ying Zhang, Tuan Trang, Patrick J Whelan. BioRxiv, 715326 (2019). DOI: https://doi.org/10.1101/715326

Kappa opioid receptors drive a tonic aversive component of chronic pain. Shiwei Steve Liu, Sarah Pickens, Nicole E Burma, Ines Ibarra-Lecue, Hongyan Yang, Lihua Xue, Chris Cook, Joshua K Hakimian, Amie L Severino, Lindsay Lueptow, Kristina Komarek, Anna MW Taylor, Mary C Olmstead, F Ivy Carroll, Caroline E Bass, Anne M Andrews, Wendy Walwyn, Tuan Trang, Christopher J Evans, Frances M Leslie, Catherine M Cahill. J Neurosci 39(21), 4162-78 (2019). DOI: https://doi.org/10.1523/JNEUROSCI.0274-19.2019

TRPV1 promotes opioid analgesia during inflammation. Lilian Basso, Reem Aboushousha, Churmy Yong Fan, Mircea Iftinca, Helvira Melo, Robyn Flynn, Francina Agosti, Morley D Hollenberg, Roger Thompson, Emmanuel Bourinet, Tuan Trang, Christophe Altier. Sci Signal 12(575), eaav0711 (2019). DOI: 10.1126/scisignal.aav0711

2018

Macrophages regulate Schwann cell maturation after nerve injury. Jo Anne Stratton, Alexandra Holmes, Nicole L Rosin, Sarthak Sinha, Mohit Vohra, Nicole E Burma, Tuan Trang, Rajiv Midha, Jeff Biernaskie. Cell Rep 24(10), 2561-2572 (2018). DOI: https://doi.org/10.1016/j.celrep.2018.08.004

Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats. Josiane CS Mapplebeck, Rebecca Dalgarno, YuShan Tu, Orla Moriarty, Simon Beggs, Charlie HT Kwok, Katherine Halievski, Sofia Assi, Jeffrey S Mogil, Tuan Trang, Michael W Salter. Pain 159(9), 1752-63 (2018). DOI: 10.1097/j.pain.0000000000001265

Microglial pannexin-1 channel activation is a spinal determinant of joint pain. Michael Mousseau, Nicole E Burma, Kwan Yeop Lee, Heather Leduc-Pessah, Charlie HT Kwok, Allison R Reid, Melissa O’Brien, Boriss Sagalajev, Jo Anne Stratton, Natalya Patrick, Patrick L Stemkowski, Jeff Biernaskie, Gerald W Zamponi, Paul Salo, Jason J McDougall, Steven A Prescott, John R Matyas, Tuan Trang. Sci Adv 4(8), eaas9846 (2018). DOI: 10.1126/sciadv.aas9846

Intrathecal delivery of a palmitoylated peptide targeting Y382-384 within the P2X7 receptor alleviates neuropathic pain. Rebecca Dalgarno, Heather Leduc-Pessah, Alexandra Pilapil, Charlie HT Kwok, Tuan Trang. Mol Pain 14, 1744806918795793 (2018). DOI: https://doi.org/10.1177/1744806918795793

TRPV1 regulates opioid analgesia during inflammation. Lilian Basso, Reem Aboushousha, Churmy Yong Fan, Mircea Iftinca, Helvira Melo, Robyn Flynn, Francina Agosti, Morley D Hollenberg, Roger Thompson, Emmanuel Bourinet, Tuan Trang, Christophe Altier. bioRxiv, 274233 (2018). DOI: https://doi.org/10.1101/274233

2017

Therapies and mechanisms of opioid withdrawal. Nicole E Burma, Charlie HT Kwok, Tuan Trang. Pain Manag. 7(6), 455-9 (2017). DOI: https://doi.org/10.2217/pmt-2017-0028

Neonatal injury results in sex-dependent nociceptive hypersensitivity and social behavioral deficits during adolescence, without altering morphine response. Nikita N Burke, Tuan Trang. J Pain 18(11), 1384-96 (2017). DOI: https://doi.org/10.1016/j.jpain.2017.07.003

Site-specific regulation of P2X7 receptor function in microglia gates morphine analgesic tolerance. Heather Leduc-Pessah, Nicholas L Weilinger, Churmy Y Fan, Nicole E Burma, Roger J Thompson, Tuan Trang. J Neurosci. 37(42), 10154-72 (2017). DOI: 10.1523/JNEUROSCI.0852-17.2017

Genetic deletion of microglial Panx1 attenuates morphine withdrawal, but not analgesic tolerance or hyperalgesia in mice. Nicole E Burma, Heather Leduc-Pessah, Tuan Trang. Channels 11(5), 487-494 (2017). DOI: https://doi.org/10.1080/19336950.2017.1359361

Pain: From genes and proteins to cells in the living organism. Charlie HT Kwok, Tuan Trang. J Neurosci Res 95(6), 1239-41 (2017). DOI: https://doi.org/10.1002/jnr.24046

Animal models of chronic pain: advances and challenges for clinical translation. Nicole E Burma, Heather Leduc‐Pessah, Churmy Y Fan, Tuan Trang. J Neurosci Res 95(6), 1242-56 (2017). DOI: https://doi.org/10.1002/jnr.23768

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents. Nicole E Burma, Robert P Bonin, Heather Leduc-Pessah, Corey Baimel, Zoe F Cairncross, Michael Mousseau, Jhenkruthi Vijaya Shankara, Patrick L Stemkowski, Dinara Baimoukhametova, Jaideep S Bains, Michael C Antle, Gerald W Zamponi, Catherine M Cahill, Stephanie L Borgland, Yves De Koninck, Tuan Trang. Nat Med. 23(3), 355-60 (2017). DOI: 10.1038/nm.4281

2016

Microglia in health and pain: impact of noxious early life events. Nikita N Burke, Churmy Y Fan, Tuan Trang. Exp Physiol 101(8), 1003-21 (2016). DOI: https://doi.org/10.1113/EP085714

Modulatory and plastic effects of kinins on spinal cord networks. S Mandadi, H Leduc‐Pessah, P Hong, J Ejdrygiewicz, SA Sharples, T Trang, PJ Whelan. J Physiol 594(4), 1017-36 (2016). DOI: https://doi.org/10.1113/JP271152